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PROTEOMIC ANALYSIS OF IL-6 EXPRESSION IN UVB IRRADIATED RAT SKIN
Abstract:
The incidence of skin cancer has significantly increased over the past decade. It is important to define the accurate etiology and the mechanisms involved in development of skin cancer to apply the appropriate preventative measures. Interleukin-6 (IL-6) is a pleiotropic cytokine that contributes in the body to a multiple biological processes. IL-6 induces the final maturation of B cells into antibody-producing cells and can enhance or inhibit the proliferation of carcinoma cells. We try to determine the serum level of IL-6 in rat with irradiated with UVB. We have used Sprague-Dawley rats UVB irradiated in comparison with control (non-irradiated) lot. UVB radiation determined a cutaneous inflammatory response at 24h after the last irradiation. The maximum inflammatory reaction was evident at 48h after the UVB exposure. Acute exposure to UVB radiations induced acute inflammatory response as evidenced by the increased level of IL-6 in serum both after 24 and 48 hours after the last irradiation. Inflammatory response to UVB radiation has been reflected clinically by apparition of erythema and local edema.

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