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OBTAINING AND CHARACTERIZATION OF POLYETHER-URETHANE NANOSTRUCTURES – A POSSIBLE DRUG CARRIER SYSTEM
Abstract:
Transdermal drug carrier systems are used to ensure a constant level of drug during the administration. Polyurethane derivatives were recently considered as possible material in the field. The study intends to obtain a possible drug carrier at nano level. Polyether-urethane (PEU) nanostructures were synthesized by using the technique of interfacial polycondensation combined to spontaneous emulsification. For synthesis, it were used an organic phase which contain lysine diisocyante ester (LDI) and a lipophilic surfactant (Span®85) in water-miscible solvent (acetone) and an homogeneous aqueous phase formed by water, diol or polyether and a hydrophilic surfactant (Tween®20 or Tween®60). The obtained nanostructures were finally characterized.

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