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SHORT CONSIDERATIONS ABOUT THERMAL ANALYSIS AND FT-IR SPECTROMETRY OF SOME PYRIMIDINE PHARMACEUTICAL COMPOUNDS
Abstract:
Pyrimidine compounds for pharmaceutical use which were analyzed belong to cardiac agents (dipiridamol, moxonidine, piribedilum) and to cholesterol lowering drugs, the statins (rosuvastatin). This paper briefly characterizes two aspects: FT – IR spectra of drugs containing these active substances, before and after thermal transformation in which they were subjected; thermal analysis of these drugs by combining thermogravimetry (TG) with diferential thermal analysis (DTA) and diferantial scanning calorimetry (DSC). The results obtained indicate: drug decomposition accompanied by cleavage of pyrimidine ring and its substitutes, changes in sample with temperature, evidence of endo-and exothermic processes.

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